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FDA-rated Active Pharmaceutical Ingredient Production

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API Synthesis Room
Glass-lined vessels can handle aggressive compounds
Our staff have expertise in running various API projects
After synthesis, purification is performed in a separate room
Finished compounds are packed in a Class 100 Clean Room

Equateq can manufacture most pharmaceutical compounds in our first class, small scale synthesis plant, which has clean rooms to class 100. All facilities and systems were installed in 1999 or later and have passed an FDA pre-approval inspection. The reactor systems have been designed for flexibility and use with corrosive chemicals, with glass lines, tantalum-clad condensers and PTFE piping.

Typical reactions and processes:

  • Grignards
  • Halogenation/Sulphanation
  • Friedel Crafts, alkylation and acylation
  • Reductions, oxidations
  • Recrystallisations
  • Chiral resolutions
  • Distillations
  • Displacements
  • Azeotropic separations

Key Pharmaceutical reactions can be conducted in our API plant Specific equipment available includes:

Synthesis:

  • 2 x 100 litre glass-lined reactors
  • Overhead condensers (carbon block and tantalum clad)
  • 20 litre Glass reactor
  • Rotary evaporator
  • S/S filter [expand "S/S"]
  • Drying oven

Purification:

  • Chromatography package
  • Rotary evaporator
  • 2 glass crystallisers

Key Pharmaceutical reactions can be conducted in our API plant Filling:

  • Laminar airflow booth
  • Filter
  • Drying oven

We are particularly well placed to produce novel compounds that include a fatty acid as part of the structure, such as:

  • Synthetic triglycerides (e.g. tri-GLA)
  • Diesters (e.g. EPA^^ArA)
  • Monoesters (e.g. DHA^^OH)
  • Salts (e.g. Lithium GLA)
  • Other novel combinatorial compounds (such as ascorbyl GLA and meglumine GLA).